A breakthrough in oncology from researchers at KAIST.
They have developed a way to turn immune cells trapped inside tumors into active cancer fighters using a direct injection. Solid tumors are often dense and hard to penetrate, but this new method uses lipid nanoparticles to deliver mRNA instructions directly to the cells already present at the tumor site.
These cells are converted into “CAR-macrophages” that can engulf cancer cells and stimulate the rest of the body’s immune system to join the fight.
In animal studies, this approach significantly reduced tumor growth and even provided body-wide immune protection.
Schematic illustration of the strategy for in vivo CAR-macrophage generation and cancer cell eradication via co-delivery of CAR mRNA and immunostimulants using lipid nanoparticles (LNPs). Credit: KAIST
Source: Scitechdaily
This topic was featured on Great News podcast episode 28
